Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions: a case study of lumefantrine

This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in early stage amorphous solid dispersion(ASD) system development by profiling excipients’ capability to solubilise, amorphisise, stabilise chosen active pharmaceutical ingredient (API) an effort rank their suitability. Lumefantrine, antimalarial compound with both poor solubility permeability, was used as model API solvent evaporation film casting prepare candidate ASD matrices this work.